William J. Irvin Jr., MD

William J. Irvin Jr., MD

Bon Secours Cancer Institute Medical Oncology at St. Francis

14051 St. Francis Boulevard
Suite 2210
Midlothian, VA 23114
Phone: 804-893-8717
Fax: 804-594-3131
Maps and Directions

Hospital Affiliations

St. Francis Medical Center



Breast Cancer Treatment


Education and Training

Hematology and Oncology Fellowship

University of North Carolina

Internal Medicine Residency

Virginia Commonwealth University School of Medicine

Medical School

Virginia Commonwealth University School of Medicine

Undergraduate Degree

University of Virginia


Dr. Irvin joined the Bon Secours Cancer Institute from faculty at the University of North Carolina where he developed a specialty in breast cancer. At North Carolina, he led a nationally recognized clinical trial on pharmacogenetic dosing of tamoxifen. His research interests include overcoming endocrine resistance in breast cancer, triple-negative breast cancer, and breast cancer in young women. He attended the University of Virginia for his undergraduate degree and received his medical degree from Virginia Commonwealth University School of Medicine. He completed his internal medicine residency from Virginia Commonwealth University. From there, Dr. Irvin completed a hematology and oncology fellowship at the University of North Carolina. Dr. Irvin is board certified by the American Board of Internal Medicine in Internal Medicine, Medical Oncology, and Hematology. For the Bon Secours Cancer Institute, Dr. Irvin is the Director of Clinical Research and the Physician Site Leader for Medical Oncology. Originally from Richmond, Dr. Irvin, his wife, and three children are excited to be home in Virginia.

Recent Publications

Books and chapters:

Irvin W, Muss H. Clinical Trials in the Elderly. In: Naeim, Reubin, and Ganz eds. Management of Cancer in the Older Patient. Philadelphia, PA: Elsevier Saunders, 2012, p. 103-108.

Irvin W, Amos K. Chapter 83: Selection of patients for therapy. In: Kuerer, ed. Kuerer’s Breast Surgical Oncology. New York, NY: McGraw-Hill Professional, 2010, p.867-875.

Irvin W, Carey LA. Breast Cancer. In: Kilzer N, ed. World Book Encyclopedia. (Electronic Product). Chicago, IL: World Book Publishing; 2008, 591.

Refereed papers/articles:

Original research:

Paoletti C, Li Y, Muñiz MC, Kidwell KM, Aung K, Thomas DG, Brown ME, Abramson VG, Irvin WJ Jr., Lin NU, Liu MC, Nanda R, Nangia JR, Storniolo AM, Traina TA, Vaklavas C, Van Poznak CH, Wolff AC, Forero-Torres A, Hayes DF; Translational Breast Cancer Research Consortium (TBCRC). Significance of Circulating Tumor Cells in metastatic triple negative breast cancer patients within a randomized, phase II trial TBCRC 019. Clin Cancer Res. 2015 Jun 15; 21 (12): 2771-9. Epub 2015 Mar 16. PMID 25779948.

Hertz DL, Snavely AC, McLeod HL, Walko CM, Ibrahim JG, Anderson S, Weck KE, Magrinat G, Olajide O, Moore S, Raad R, Carrizosa DR, Corso S, Schwartz G, Pepperson JM, Evans JP, Jones DR, Desta Z, Flockhart DA, Carey LA, Irvin WJ Jr. Br J Clin Pharmacol. 2015 Apr 24. Epub ahead of print. PMID 25907378.

Forero-Torres A, Varley KE, Abramson VG, Li Y, Vaklavas C, Lin NU, Liu MC, Rugo HS, Nanda R, Storniolo AM, Traina TA, Patil S, Van Poznak CH, Nangia JR, Irvin WJ Jr., Krontiras H, De Los Santos JF, Haluska P, Grizzle W, Meyers RM, Wolff AC; Translational Breast Cancer Research Consortium (TBCRC). TBCRC 019: An phase II trial of nanoparticle albumin-bound paclitaxel with or without the anti-death receptor 5 monoclonal antibody tigatuzumab in patients with metastatic triple negative breast cancer. Clin Cancer Res. 2015 Jun 15; 21 (12): 2722-9; Epub 2015 Mar 16. PMID 25779953.

Click here to view complete list of Dr. Irvin's publications 


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